News
Selected coverage and commentary on work from the lab and our collaborators.
Age identifies cancer drivers hidden within the genome
A perspective on the lab’s framework for separating mutations that help clones thrive from mutations that actually cause cancer.
Read the storyA new way to think about age and cancer genetics
Coverage of the lab’s method for distinguishing cancer-driving mutations from mutations that accumulate with age.
Read the story“Colorectal cancer is an increasing public health problem”
Kamila discusses the growing burden of early-onset colorectal cancer and the importance of sustained support for cancer research.
Read the storyPolyguanine microsatellites are robust replication clocks in cancer
Gejman and Izar discuss the lab’s use of polyguanine tracts to quantify cell divisions along cancer lineages.
Read the storyLatent spaces for tumour transcriptomes
Commentary on deep-learning approaches that reveal shared and cancer-specific patterns across 18 tumour types.
Read the storyClonal haematopoiesis and atherosclerosis: a chicken or egg question?
Sánchez-Cabo and Fuster consider the bidirectional relationship between clonal haematopoiesis and atherosclerosis.
Read the storyA vicious circle in coronary heart disease
A research highlight on the feedback between atherosclerosis, stem-cell proliferation and clonal haematopoiesis.
Read the storyA vicious cycle in atherosclerosis
Lusis previews evidence that atherosclerosis can stimulate the expansion of mutant blood-cell clones.
Read the storyAtherosclerosis can accelerate clonal hematopoiesis
Coverage of work connecting cardiovascular inflammation, stem-cell proliferation and the expansion of mutant blood-cell clones.
Read the storyNavigating the path to distant metastasis
Graham and Shibata discuss the lab’s discovery that distant metastasis passes through a tighter evolutionary bottleneck.
Read the storyA wider evolutionary bottleneck in distant metastasis
A concise look at why lymph-node metastases can be founded by many cells while spread to distant organs is more restrictive.
Read the storyRethinking the route from lymph nodes to distant metastases
Coverage of the lab’s reconstruction of colorectal-cancer family trees and what they reveal about metastatic spread.
Read the storyExposing cancer cells' family tree
Coverage of the lab’s reconstruction of colorectal-cancer lineages and the origins of lymphatic and distant metastases.
Read the story